Background: The incidence of diabetes is increasing rapidly with interference in electrolytes sodium (Na+), potassium
(K+) and chloride (Cl-). This work was designed to study the effects of co-administration of Lycopene and/or Zinc on
Serum Electrolyte in Alloxan- Induced Diabetic Wistar Rat.
Material and Methods: Healthy albino rats weighing between 150g and 200g were used. The rats were randomly
allotted into six groups, each containing five albino rats respectively. Five of the groups ( II,III IV V and VI) were induced
with diabetes by single intraperitoneal (i.p) injection of freshly prepared in 0.1 mol/L citrate buffered solution (pH 4.5)
of streptozotocin (Sigma Aldrich, St. Louis, MO, USA) at a dose of 150 mg/kg body weight. Control (vehicle) rats were
injected with equal volume of 0.1 mol/L citrate buffer. Four days after Alloxan injection, diabetes induction was confirmed
by measuring fasting blood glucose level in a tail vein blood samples using ACCU-CHEK compact plus glucometer
(Roche, France). Rats with glucose level of 200 mg/dl or higher were considered as diabetic. After the induction of
diabetes the rats were treated using the Lycopene and Zinc separately and in combination respectively according to
group daily, whereas, the other group (I) was not given any treatment and this served as the normal control, providing
a baseline data.
Results: The diabetic treated groups had significantly (P < 0.05) higher serum Na+ concentration than the diabetic
control group. The diabetic treated groups had significantly (P < 0.05) lower serum K+ concentration than the diabetic
control. Also, the diabetic treated groups had significantly (P < 0.05) higher Clô€€€ concentration than the diabetic control
group. The diabetic treated group had significantly (P < 0.05) lower HCO3
ô€€€ concentration than the diabetic control
group. The diabetic treated groups had significantly (P < 0.05) lower serum urea concentration when compared to the
diabetic control. The diabetic treated groups showed significantly (P < 0.05) decrease in serum creatinine concentration
as compared to the diabetic control group.
Conclusion: These anomalies were all ameliorated to about normal values after four weeks of treatment with
Lycopene+Zinc. This suggests the synergistic beneficial effects of lycopene acid and zinc against alloxan-induced
diabetes in Wistar Rats.
Effects of Co-Administration of Lycopene and / or Zinc on Serum Electrolyte In Alloxan- Induced Diabetic Wistar Rat
- Goji A.D.T
- Muhammed K.A
- Tende J.A
- Aisha I
Goji A.D.T
Department of Human Physiology, College of Medicine Kaduna State University, Kaduna- (+234) Nigeria
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Muhammed K.A
Department of Human Physiology, College of Health Sciences, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria- (+234) Nigeria.
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Tende J.A
Department of Human Physiology, College of Health Sciences, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria- (+234) Nigeria.
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Aisha I
Department of Human Physiology, College of Health Sciences, Faculty of Basic Medical Sciences, Ahmadu Bello University, Zaria- (+234) Nigeria.
Search for the other articles from the author in:
Google Scholar | PubMed | BMJ Journal
Cite this:
A.D.T, G., K.A, M., J.A, T., & I, A. (2018). Effects of Co-Administration of Lycopene and / or Zinc on Serum Electrolyte In Alloxan- Induced Diabetic Wistar Rat. Journal of Medical Biomedical and Applied Sciences, 6(6), 57–61. https://doi.org/10.15520/jmbas.v6i6.115
Copyright @ 2022 Interactive Protocols
Share
