Diabetes mellitus is a severe endocrine disorder characterized by high blood glucose levels owing to the complete or relative absence of insulin secretion or action. Presently available medicines for DM have numerous adverse effects. Therefore, it is needed to investigate novel methods to improve DM treatment. Thus plant-based management could be a possible strategy. Therefore, current study was designed to evaluate the anti-diabetic and anti- hyperglycemic activity of the Verbascum thapsus in alloxan induced diabetic mice.Alloxan was injected intraperitonially (150 mg/kg,b.w) to induce diabetes in mice. The mice were divided into five groups (n=10); group 1 (normal control) received normal food and water, group 2 (diabetic control) received normal food and clean water, group 3 (diabetic mice) received 200 mg of the methanolic plant extract), group 4 (diabetic mice) received 400 mg of the methanolic extract) , and group 5 (diabetic mice) received the standard drug, Glibenclamide (10mg) for 28 days. Glucose was measured four times and after 28 days, blood samples were collected to measure the lipid profile.Result shows that methanolic extract of V thapsus significantly (P>0.05) reduced the blood glucose, level, TC, TG, LDL, increase in HDL and body weight at 400mg/kg compared to 200 mg and 10 mg of the standard drug after 28 days of treatment.The results of current study suggested that methanolic extract of V thapsus has potent anti-diabetic activity, with no toxicity.
Methanolic Extract of Verbascum Thapsus Ameliorates Hyperglycemia and Hyperlipidemia in Alloxan-Induced Diabetic Albino Mice
- Waheed Khan
Waheed Khan
Department of zoology Hazara university Mansehra kpk Pakistan
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Cite this:
Waheed Khan. (2021). Methanolic Extract of Verbascum Thapsus Ameliorates Hyperglycemia and Hyperlipidemia in Alloxan-Induced Diabetic Albino Mice. Journal of Medical Biomedical and Applied Sciences, 9(7), 721–728. Retrieved from http://jmbm.in/index.php/jmbas/article/view/304
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