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Effect of Cadmium Exposure on Zinc Levels in Normal Non-Diabetic and Diabetic Rats Induced by Streptozotocin

  • N’ Guessan Assue Adja Julien
  • Adon Mousan Arsène
  • Konan Kouassi Martin
  • Djaman Allico Joseph
  • Dosso Mireille
Cite this:
N’ Guessan Assue Adja Julien, Adon Mousan Arsène, Martin , K. K. ., Djaman Allico Joseph, & Dosso Mireille. (2020). Effect of Cadmium Exposure on Zinc Levels in Normal Non-Diabetic and Diabetic Rats Induced by Streptozotocin. Journal of Medical Biomedical and Applied Sciences, 8(8), 507–512. https://doi.org/10.15520/jmbas.v8i8.236
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Abstract

Diabetic rats induced by streptozotocin and normal non-diabetic rats were exposed to cadmium
sulphate in drinking water at a dose of 200 mg / L for 30 days. At the end of the exposure, the
blood, kidney and pancreas of each rat were taken for the determination of cadmium and zinc.
The results show a significant increase in the level of cadmium in the blood, kidney and
pancreas of normal non-diabetic rats and diabetic rats compared to the control group. The
cadmium concentration was significantly higher in plasma and tissues in diabetic rats compared
to normal non-diabetic rats. Cadmium poisoning resulted in a significant decrease in the level
of zinc in the blood and tissues of normal non-diabetic rats and diabetic rats compared to their
respective controls. This study reveals that diabetic rats induced by streptozotocin are more
sensitive to the toxic effects of cadmium than normal rats.
Key words: Cadmium, zinc, plasma, pancreas, kidneys, diabetes

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