Pluricarential Anemia Secondary To Autoimmune Atrophic Gastritis In A Young Female: Case Report
10.15520/jmbas.v7i5.189
Resumen
value according to age and gender, and corresponds to a major global health problem.
Most anemias originate from deficiency syndromes, and their etiology must always be
investigated.
Case Report: We report a 29-year-old female patient with refractory iron deficiency
anemia,even afterseveral attempts to oral iron replacement, associated with less pronounced
vitamin B12 deficiency. Pluricarential anemia and unresponsiveness to oral
iron in therapeutic dosestriggered the diagnostic hypothesis of disabsorptive syndrome.
Upper gastrointestinal endoscopy showed moderate gastric atrophy with active gastritis
by histological evaluation and negative search for H. pylori. The evaluation of clinical,
endoscopic and laboratory data (gastrin increase and positivity for anti-parietal
cell antibody) provided the diagnosis of autoimmune atrophic gastritis. Parenteral
replacements of iron and vitamin B12 were performed with good response and the patient
is been followed up with hematologists and gastroenterologists.Thus, wereport a
case of a young patient with an uncommon presentation of iron deficiency.
Discussion: The non-responsiveness to oral iron replacement should trigger research
into some disabsorptive clinical entities such as celiac disease, Helicobacter pylori infection
and autoimmune atrophic gastritis.The latter may manifest with pluricarential
syndromes (in particular by vitamin B12 deficiency, usually more pronounced, and
iron deficiency).Nutrients malabsorption in autoimmune atrophic gastritis is due to
blockade in H + / K + ATP-ase pump due to antibodies.
Conclusion: Inadequate etiological investigation of anemia is an important cause
of non-responsiveness to proposed treatments, with considerable morbidity for the
population involved and expenditures for health care.
How to Cite
Gabriela Spacek da Fonseca, Maria Amélia Pinheiro Camargo Plazzi, Raphaela Silva, Maria Luiza Gonçalves dos Reis Monteiro (2019). Pluricarential Anemia Secondary To Autoimmune Atrophic Gastritis In A Young Female: Case Report. Journal of Medical Biomedical and Applied Sciences , Vol. 7 Núm. 5 (2019) , 241-243 . https://doi.org/10.15520/jmbas.v7i5.189