The concept of β-lactam antibiotics in combination with β-lactamase inhibitor to combat β-lactamase producing organism is a scientific norm for therapeutic success. This study seeks to compare some biopharmaceutical and microbiological parameters of selected ceftriaxone-sulbactam brands available in Nigeria with Rocephin®, as standard, with respect to efficacy and safety. Physical, physicochemical and microbiological tests for quality evaluation were performed alongside clinical / microbiological evaluations using typed and clinical isolates as indices for efficacy. The tested brands were adjudged satisfactory with respect to labeling and drug presentation. Two samples, SB-C and SB-D, revealed chemical contents lower than 90% for either ceftriaxone and/or sulbactam. However, all samples revealed satisfactory and similar microbiological safety and efficacy characteristics. Products SB-A, SB-B, SB-E, SB-F and SB-G demonstrated significantly higher antibacterial activity than the standard, (p<0.05). Samples SB-C and SB-D were not chemically equivalent to the other generic products of ceftriaxone-sulbactam evaluated. The presentation of ceftriaxone with β-lactamase inhibitor demonstrated similar biopharmaceutical properties but superior antimicrobial properties/ efficacy than the standard
Biopharmaceutical And Microbiological Evaluation of Some Ceftriaxone-Sulbactam Products for Safety and Efficacy
Evaluation of ceftrixone-sulbactam for safety and efficacy
- Sunday Awofisayo
- Dr
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- Dr
- Prof
Sunday Awofisayo
a:1:{s:5:"en_US";s:17:"University of Uyo";}
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Dr
Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, university of Uyo, Nigeria
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Ms
Department of Food Technology, Akwa Ibom State Polytechnic, Ikot Osurua, Akwa Ibom State, Nigeria
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Department of Pharmaceutical Microbiology and Biotechnology, faculty of Pharmacy, University of Uyo
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Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
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Cite this:
Awofisayo, S., Awofisayo, S. O., Eyen, N. O. ., Agboke, A. A., & Arhewoh, M. I. (2022). Biopharmaceutical And Microbiological Evaluation of Some Ceftriaxone-Sulbactam Products for Safety and Efficacy: Evaluation of ceftrixone-sulbactam for safety and efficacy. Journal of Medical Biomedical and Applied Sciences, 10(6), 3154–3160. Retrieved from https://jmbm.in/index.php/jmbas/article/view/270
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