Dental pulp stem cells (DPSCs) are a promising source of cells for numerous and varied regenerative medicine applications. Their natural function in the production of odontoblasts to create reparative dentin support applications in dentistry in the regeneration of tooth structures. Numerous studies have provided evidence of DPSCs’ differentiation capacity, such as in neurogenesis, adipogenesis, osteogenesis, chondrogenesis, angiogenesis, and dentinogenesis. The molecular mechanisms and functions of DPSCs’ differentiation process are affected by growth factors and scaffolds. For example, growth factors such as basic fibroblast growth factor (bFGF), transforming growth factor-β (TGF-β), nerve growth factor (NGF), platelet-derived growth factor (PDGF), and bone morphogenic proteins (BMPs) influence DPSC fate, including in differentiation, cell proliferation, and wound healing. It is clear that a deep understanding of the mechanisms of stem cells, including their aging, self-renewal, microenvironmental homeostasis, and differentiation correlated with cell activity, the energy for which is provided from mitochondria, should provide new approaches for DPSC research and therapeutics.
Dental Pulp Stem Cells (DPSCs): An Overview
- Kalpna Thakur
- Rubeena Anjum
- Rajesh Thakur
- Nitish Bhat
- Akanksha Dhiman
- Deepti Garg
Kalpna Thakur
Lecturer, Department of Oral Pathology and Microbiology, H.P.Govt. Dental College and Hospital, Shimla, Himachal Pradesh
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Rubeena Anjum
Professor & HOD, Department of Oral and Maxillofacial Pathology and Oral Microbiology, Indira Gandhi Govt. Dental College, Jammu, Jammu and Kashmir
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Rajesh Thakur
Lecturer (Designated), Department of Conservative Dentistry and Endodontics, H.P. Govt. Dental College and Hospital, Shimla, Himachal Pradesh
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Nitish Bhat
Registrar, Department of Oral and Maxillofacial Pathology and Oral Microbiology, Indira Gandhi Govt. Dental College, Jammu, Jammu and Kashmir
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Akanksha Dhiman
Senior Lecturer, Department of Conservative Dentistry and Endodontics, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh
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Deepti Garg
Senior Lecturer, Department of Prosthodontics and Crown and Bridge, Maharishi Markandeshwar College of Dental Sciences and Research, Mullana, Ambala, Haryana
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Cite this:
Kalpna Thakur, Rubeena Anjum, Rajesh Thakur, Nitish Bhat, Akanksha Dhiman, & Deepti Garg. (2021). Dental Pulp Stem Cells (DPSCs): An Overview. Journal of Medical Biomedical and Applied Sciences, 9(9), 771–775. Retrieved from https://jmbm.in/index.php/jmbas/article/view/313
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