The present study was designed to assess the comparative bio-equivalence of Flumisol®and Maquin® in healthy
broiler chickens after oral administration of both products in a dose of 12 mg flumequine /kg.b.wt. Twenty four broiler
chickens were divided equally into two groups (12 chickens for each group). The first group was designed to study the
pharmacokinetics of Flumisol®, while the 2nd group was designed to study the pharmacokinetics of Maquin®. Each
broiler chicken in both groups was orally administered with 12 mg flumequine /kg b.wt. Blood samples were obtained
from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after
a single oral administration. The disposition kinetics of Flumisol® and Maquin® following oral administration of 12 mg
flumequine/kg b.wt, revealed that the maximum blood concentration [Cmax] were 1.88 and 1.76 g/ml, attained at [tmax]
of 1.42 and 1.41 hours, respectively.
In conclusion: Maquin® is bioequivalent to Flumisol® since the ratios of Cmax, AUC0􀀀24 and AUC0􀀀1 (T/R) were
0.93, 0.89 and 0.88, respectively. These are within the Bio-equivalence acceptance range. Flumisol® and Maquin®
are therefore bioequivalent and interchangeable.
Bio-equivalence Study of Two Oral Flumequine Formulations (Flumisol® and Maquin®) in Broiler Chickens
- Saber El-Hanbally
Saber El-Hanbally
Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt
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Cite this:
El-Hanbally, S. (2016). Bio-equivalence Study of Two Oral Flumequine Formulations (Flumisol® and Maquin®) in Broiler Chickens. Journal of Medical Biomedical and Applied Sciences, 3(12), 1–5. https://doi.org/10.15520/jmbas.v3i12.168
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