Aim: This study aims to investigate whether there is a relationship between serum
5-HT levels and insomnia and depression in the elderly population aged 60 years..
Methods: Subjects in this retrospective study were 40 elderly people in Pucang-
Gading Nursing Home, Semarang, Central Java, Indonesia. 27 elderly people were
diagnosed with insomnia. Serum serotonin level were measured in elderly with and
without insomnia. Bi-and multi-variate logistic regression were used to evaluate the
impact of serotonin to predict insomnia.
Results: The median age of the whole population was 70 years and 90.0% were female.
Elderly with serum serotonin level below 35,6ng/mL have 21,600 risk of developing
insomnia compare to those with serum serotonin level more than 35,6 ng/mL (p
= 0,000). In bivariate analysis, low serotonin level was significantly associated with
insomnia. In multivariate analysis, serotoninwas an independent prognostic factor for
insomnia (p = 0,001, OR = 0,046, 95%CI). The AUC for serotonin was 0,846 (95%
CI = 0,708 s/d 0,958 p< 0,001).
Conclusions: We identified serum serotonin level predictive to insomnia in elderly.
Serum Serotonin, A Good Indicator of Insomnia And Depression In Elderly
- Retnaning sih
Retnaning sih
Neurology Dept, Medical Faculty, Diponegoro University/Dr. Kariadi General Hospital, Semarang, Central Java, Indonesia.
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Cite this:
sih, R. (2019). Serum Serotonin, A Good Indicator of Insomnia And Depression In Elderly. Journal of Medical Biomedical and Applied Sciences, 7(5), 230–240. https://doi.org/10.15520/jmbas.v7i5.188
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