Articles

Biopharmaceutical And Microbiological Evaluation of Some Ceftriaxone-Sulbactam Products for Safety and Efficacy: Evaluation of ceftrixone-sulbactam for safety and efficacy

  • Sunday Awofisayo
    a:1:{s:5:"en_US";s:17:"University of Uyo";}
  • Dr
    Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, university of Uyo, Nigeria
  • Ms
    Department of Food Technology, Akwa Ibom State Polytechnic, Ikot Osurua, Akwa Ibom State, Nigeria
  • Dr
    Department of Pharmaceutical Microbiology and Biotechnology, faculty of Pharmacy, University of Uyo
  • Prof
    Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Published 2022-09-19 Issue Vol. 10 No. 6 (2022) Pages 3154-3160 Section Articles
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Abstract

The concept of β-lactam antibiotics in combination with β-lactamase inhibitor to combat β-lactamase producing organism is a scientific norm for therapeutic success. This study seeks to compare some biopharmaceutical and microbiological parameters of selected ceftriaxone-sulbactam brands available in Nigeria with Rocephin®, as standard, with respect to efficacy and safety. Physical, physicochemical and microbiological tests for quality evaluation were performed alongside clinical / microbiological evaluations using typed and clinical isolates as indices for efficacy. The tested brands were adjudged satisfactory with respect to labeling and drug presentation. Two samples, SB-C and SB-D, revealed chemical contents lower than 90% for either ceftriaxone and/or sulbactam. However, all samples revealed satisfactory and similar microbiological safety and efficacy characteristics. Products SB-A, SB-B, SB-E, SB-F and SB-G demonstrated significantly higher antibacterial activity than the standard, (p<0.05). Samples SB-C and SB-D were not chemically equivalent to the other generic products of ceftriaxone-sulbactam evaluated. The presentation of ceftriaxone with β-lactamase inhibitor demonstrated similar biopharmaceutical properties but superior antimicrobial properties/ efficacy than the standard

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How to Cite

Sunday Awofisayo, Dr, Ms, Dr, Prof (2022). Biopharmaceutical And Microbiological Evaluation of Some Ceftriaxone-Sulbactam Products for Safety and Efficacy: Evaluation of ceftrixone-sulbactam for safety and efficacy. Journal of Medical Biomedical and Applied Sciences , Vol. 10 No. 6 (2022) , 3154-3160 .